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KMID : 0613820180280121455
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Journal of Life Science
2018 Volume.28 No. 12 p.1455 ~ p.1460
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Salicylate Can Enhance Osteogenic Differentiation of Human Periosteum- derived Mesenchymal Stem Cells
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Kim Bo-Gyu
Lee A-Ram
Lee Bo-Young
Shim Sung-Bo
Moon Dong-Kyu
Hwang Sun-Chul
Byun June-Ho
Woo Dong-Kyun
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Abstract
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Due to a rapidly expanding aging population, the incidence of degenerative bone disease has increased, and efforts to handle the issue using regenerative medicine have become more important. In order to control various bone diseases such as osteoarthritis and osteoporosis, regenerative medicine utilizing adult stem cells has been extensively studied. And it is now clear that the mitochondrial energy metabolism, oxidative phosphorylation, is important for the process of stem cell differentiation. Interestingly, a recent study reported that salicylate promotes mitochondrial biogenesis by regulating the expression of PGC-1α in murine cells. However, the possible effects of salicylate on osteogenic differentiation through increased mitochondrial biogenesis in stem cells remain unknown. Thus, here we investigated whether salicylate could influence osteogenic differentiation and mitochondrial biogenesis of periosteum-derived mesenchymal stem cells (POMSCs). We found that salicylate treatments of POMSCs undergoing osteogenic differentiation increased the activity of alkaline phosphatase, a well-known early marker of bone cell differentiation. In addition, we observed that mitochondrial mass was increased by salicylate treatments in POMSCs. Together, these results indicate that salicylate can enhance osteogenic differentiation and mitochondrial biogenesis in POMSCs. Therefore, the findings in this study suggest that small molecules augmenting mitochondrial function such as salicylate can be a novel modulator for osteogenic differentiation and regenerative medicine.
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KEYWORD
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Differentiation, mitochondria, osteogenesis, regenerative medicine, stem cell
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